Influence of VDR gene polymorphisms on the development and course of breast cancer

Annotation. Breast cancer is the most common diagnosed in women. In last 5 years, it has been 7.8 million women, and 2020, 685,000 deaths from breast were registered. The growing number of patients with this pathology cost therapy creates a need to study new methods diagnosis treatment. Therefore, detailed attention paid genetic risk factors for cancer, particular, VDR gene its polymorphisms ApaI, TaqI, BsmI FokI. purpose review collect analyze currently known information about these SNPs their relationship development, course effectiveness To do this, an extensive literature was conducted using basic databases, which described effect vitamin D3 on tumor process found that receptor dysfunction increases affects sensitivity treatment, proves polymorphisms. FokI development pathology. prospects further research are prognostic value each polymorphism develop treatments disease.